Pandemic Influenza: A Potential Role for Statins in Treatment and Prophylaxis
Identifieur interne : 000310 ( France/Analysis ); précédent : 000309; suivant : 000311Pandemic Influenza: A Potential Role for Statins in Treatment and Prophylaxis
Auteurs : David S. Fedson [France]Source :
- Clinical Infectious Diseases [ 1058-4838 ] ; 2006.
Abstract
The next influenza pandemic may be imminent. Because antiviral agents and vaccines will be unavailable to people in most countries, we need to determine whether other agents could offer clinical benefits. Influenza is associated with an increase in acute cardiovascular diseases, and influenza viruses induce proinflammatory cytokines. Statins are cardioprotective and have anti-inflammatory and immunomodulatory effects, and they thus might benefit patients with influenza. This hypothesis should be evaluated by using administrative databases to search for reduced rates of hospitalization and death due to influenza-related conditions among people taking statins. These studies should be followed by laboratory studies of statins in animal and cell-based models of influenza virus infection and, later, by clinical trials. Positive results from such studies would provide physicians in all countries with something to offer patients for treatment and prophylaxis of pandemic influenza. Generic statins will be widely distributed and inexpensive. They might be the only agents that could alter the course of a global pandemic.
Url:
DOI: 10.1086/505116
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001878
- to stream Istex, to step Curation: 001878
- to stream Istex, to step Checkpoint: 001480
- to stream Main, to step Merge: 004270
- to stream Main, to step Curation: 004054
- to stream Main, to step Exploration: 004054
- to stream France, to step Extraction: 000310
Links to Exploration step
ISTEX:5780397B5BB3C8E6D6600AA8D36DDDB746140E30Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Pandemic Influenza: A Potential Role for Statins in Treatment and Prophylaxis</title>
<author wicri:is="90%"><name sortKey="Fedson, David S" sort="Fedson, David S" uniqKey="Fedson D" first="David S." last="Fedson">David S. Fedson</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:5780397B5BB3C8E6D6600AA8D36DDDB746140E30</idno>
<date when="2006" year="2006">2006</date>
<idno type="doi">10.1086/505116</idno>
<idno type="url">https://api.istex.fr/ark:/67375/HXZ-5NVQH1HN-M/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001878</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001878</idno>
<idno type="wicri:Area/Istex/Curation">001878</idno>
<idno type="wicri:Area/Istex/Checkpoint">001480</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001480</idno>
<idno type="wicri:doubleKey">1058-4838:2006:Fedson D:pandemic:influenza:a</idno>
<idno type="wicri:Area/Main/Merge">004270</idno>
<idno type="wicri:Area/Main/Curation">004054</idno>
<idno type="wicri:Area/Main/Exploration">004054</idno>
<idno type="wicri:Area/France/Extraction">000310</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Pandemic Influenza: A Potential Role for Statins in Treatment and Prophylaxis</title>
<author wicri:is="90%"><name sortKey="Fedson, David S" sort="Fedson, David S" uniqKey="Fedson D" first="David S." last="Fedson">David S. Fedson</name>
<affiliation wicri:level="1"><country wicri:rule="url">France</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Clinical Infectious Diseases</title>
<title level="j" type="abbrev">Clinical Infectious Diseases</title>
<idno type="ISSN">1058-4838</idno>
<idno type="eISSN">1537-6591</idno>
<imprint><publisher>The University of Chicago Press</publisher>
<date type="published">2006</date>
<biblScope unit="vol">43</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="199">199</biblScope>
<biblScope unit="page" to="205">205</biblScope>
</imprint>
<idno type="ISSN">1058-4838</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1058-4838</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">The next influenza pandemic may be imminent. Because antiviral agents and vaccines will be unavailable to people in most countries, we need to determine whether other agents could offer clinical benefits. Influenza is associated with an increase in acute cardiovascular diseases, and influenza viruses induce proinflammatory cytokines. Statins are cardioprotective and have anti-inflammatory and immunomodulatory effects, and they thus might benefit patients with influenza. This hypothesis should be evaluated by using administrative databases to search for reduced rates of hospitalization and death due to influenza-related conditions among people taking statins. These studies should be followed by laboratory studies of statins in animal and cell-based models of influenza virus infection and, later, by clinical trials. Positive results from such studies would provide physicians in all countries with something to offer patients for treatment and prophylaxis of pandemic influenza. Generic statins will be widely distributed and inexpensive. They might be the only agents that could alter the course of a global pandemic.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Fedson, David S" sort="Fedson, David S" uniqKey="Fedson D" first="David S." last="Fedson">David S. Fedson</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000310 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000310 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= France |étape= Analysis |type= RBID |clé= ISTEX:5780397B5BB3C8E6D6600AA8D36DDDB746140E30 |texte= Pandemic Influenza: A Potential Role for Statins in Treatment and Prophylaxis }}
This area was generated with Dilib version V0.6.33. |